Associate Professor Szoeke has an honours degree in Genetics and Pharmacology, MBBS and FRACP with specialisation in Neurology and subspecialisation in Epileptology. Her PhD in epidemiology. She has strong research and clinical experience with neurology, epilepsy, general medicine and aging. She has had formal training in statistics, EEG, and commercialisation courses. Her PostDoc Fellowship, conducted between Stanford University and the University of Melbourne, examines both cognition and whole genome association studies. Current research areas include both women’s healthy ageing and genetic predisposition studies. She is associate chief investigator on a multi-centre hospital-based prospective study of first-ever seizure in adults examining the pharmacogenetics of antiepileptic medications and associate chief investigator on the MWMHP extension study the Women’s Health Ageing Project (WHAP).
The Melbourne Women’s Midlife Health Project (MWMHP) is a longitudinal prospective study examining women over the menopause. There is over a decade of longitudinal data on these women and the W.H.A.P. extension study examines factors important in healthy ageing. With the benefit of these extensive longitudinal prospective earlier life measures, this study has the potential to provide important information on aspects to improve quality of life, function, mood and reduce morbidity in ageing”
Current Research Projects
Teaching Areas
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General Medicine
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General Neurology
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Women’s Health
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Epilepsy
Research Areas
Other Appointments
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Consultant Neurologist, Melbourne Health, Royal Park Campus
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Director, Neurodegenerative Diseases, Mental Disorders and Brain Health Research in the Preventive Health Division, CSIRO.
Publications
Refereed Journal article
Szoeke C, Dennerstein L. Therapy of female sexual dysfunction. Zentralbl Gynakol 2002;124(2):84-95.
Szoeke CEI, Parsons MW, Butcher KS, et al. Acute stroke thrombolysis with intravenous tissue plasminogen activator in an Australian tertiary hospital. Med J Aust 2003;178(7):324-8.
Davis SM, Parsons MW, Butcher KS, et al. Thrombolysis for acute ischaemic stroke: revisting the evidence - Reply. Med J Aust 2003;179(7):388-9.
Taylor I, Butzkueven H, Litewka L, et al. Serial MRI in multiple sclerosis: a prospective pilot study of lesion load, whole brain volume and thalamic atrophy. J Clin Neurosci 2004;11(2):153-158.
Szoeke CE, Cicuttini F, Guthrie J, Dennerstein L. Self-reported arthritis and the menopause. Climacteric 2005;8(1):49-55.
Szoeke C, Dennerstein L, Guthrie J, Clark M, Cicuttini F. The relationship between prospectively assessed body weight and physical activity and prevalence of radiological knee osteoarthritis in postmenopausal women. J Rheumatol 2006;33(9):1835-40.
Szoeke CE, Cicuttini FM, Guthrie JR, Clark MS, Dennerstein L. Factors affecting the prevalence of osteoarthritis in healthy middle-aged women: data from the longitudinal Melbourne Women's Midlife Health Project. Bone 2006;39(5):1149-55.
Szoeke CE, Newton M, Wood JM, et al. Update on pharmacogenetics in epilepsy: a brief review.Lancet Neurol 2006;5(2):189-96.
Cavalleri GL, Weale ME, Shianna KV, et al. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Lancet Neurol 2007;6(11):970-80.
Szoeke CE, Cicuttini FM, Guthrie JR, Dennerstein L. The relationship of reports of aches and joint pains to the menopausal transition: a longitudinal study. Climacteric 2008;11(1):55-62.
Szoeke CE, Dennerstein L, Wluka AE, et al. Physician diagnosed arthritis, reported arthritis and radiological non-axial osteoarthritis. Osteoarthritis and Cartilage 2008;16(7):846-50.
Szoeke C, Mackay M, Gordon A, Bladin C. Thrombolysis for Paediatric Ischaemic Stroke. J Clinical Neuroscience 2008; submitted.
Petrovski, S., Szoeke, C. E., D'Souza, W. J., Sheffield, L. J., Huggins, R. M., and O'Brien, T. J. 'A multi-SNP predictor for drug outcome in complex diseases', Epilepsia 2008; 49: 478-479.
Petrovski S, Szoeke C, Sheffield L, D’Souza W, Huggins R, O’Brien T. A Multi-SNP pharmacogenomic classifier is superior to single SNP models for predicting drug outcome in complex diseases. Pharmacogenet Genomics 2009; 19(2): 147-152
Szoeke C, Sills GJ, Kwan P, et al. Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: Data from International Pharmacogenetic Cohorts. Epilepsia 2009:50(7) 1689-1696.
Ellis KA, Bush AI, Darby D, De Fazio D, Foster J, Hudson P, et al. The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease. Int Psychogeriatr 2009 May 27:1-16.
Ryan J, Burger HG, Szoeke C, Lehert P, Ancelin ML, Henderson VW, et al. A prospective study of the association between endogenous hormones and depressive symptoms in postmenopausal women. Menopause 2009;16(3):509-17.
Books/Chaptors
Szoeke C. Mathathionin resistance in Lucilia Cuprina. Honours Thesis, University of Melbourne, Genetics Library 1995.
Szoeke C. Osteoarthritis, menopause and aging. PhD Thesis, University of Melbourne, Balieu Library 2007.
Szoeke C, Campbell S, Chiu E, Ames D. Vascular Cognitive Disorder. In : Textbook of Alzheimer Disease and Other Dementias Eds Myron Weiner & Anne Lipon 2008; The American Psychiatric Publishing, Washington DC. In Press.
Other Articles
Szoeke CEI, Chavet M, Noutsos T. A Closer Look. Video and appendage paper. Part of a research package presented to the Port Pirie council 1998.
Szoeke C, Peart A, Bammer G, Audera C. Recreational Water Use in Remote Indigenous Communities. . Co-operative Research Centre for Water Quality and Treatment & The National Centre for Epidemiology and Public Health, the Australian National University 2000.
Szoeke C. Higher Szoeke C. Higher levels of DHEAS associated with better cognitive function. NAMS First to Know e-Newsletter. May 27, 2008. (Editorial/Commentator)
Referred Published Abstracts
Szoeke C, Dennerstein L, Cicuttini F, Guthrie J, Taffe J. Osteoarthritis, menopause and aging. Climacteric 2002;5(Suppl 1):206.
Szoeke C, Desmond P, Kilpatrick C, Matkovic Z, Tress B, O’Brien T. Pilot study of the utility of diffusion tensor MRI in lateralising non-lesional TLE. . Epilepsia 2004;45(Suppl 7): 116.
Praveen K, O’Brien T, Szoeke C, Foote S. Linkage analysis of familial partial epilepsy with variable foci. Epilepsia 2004;45(Suppl 7):225.
Szoeke C, Cicuttini F, Guthrie J, Clark M, Dennerstein L. Factors affecting the development of osteoarthritis across the menopausal transition. Menopause 2004;11(6):652.
Szoeke C, Meckes-Ferber S, Sheffield L, et al. The outcome of first seizure clinics: An Australian prospective study. Epilepsia 2005;46(Suppl 6):s259.
Szoeke C, Sheffield L, Newton M, et al. Pharamcogenetics in Epilepsy: An Australian prospective study. J Clinical Neuroscience 2005;238(S1):526.
Szoeke CEI, Sills G, Kwan P, Newton M, et al. Abstract 449: Multidrug resistant (MDR1) genotype & seizure recurrence in newly treated epilepsy: Data from international prospective AED pharmacogenetic studies. J Clin Neruoscience 2008;15(3):359.
Petrovski S, Szoeke CEI, D’Souza W, Sheffield LJ, Huggins RM, O’Brien TJ. “A Multi-SNP pharmacogenomic classifier is superior to single SNP models for predicting drug outcome in complex diseases.” American Epilepsy Society. December 2008.
Szoeke C, Petrovski S, Diduttinin F, et al. “The significance of aches and joint pain reports across the menopausal transition – A longitudinal Study”. Meeting Abstracts of the 12th World congress on the Menopause. Climacteric 2008;11(2):OR7-06 102.
Sheffield LJ, Petrovski S, Gasko H, Szoeke CEI, Goldstein DB, Cavalleri G & O’Brien TJ “Analysis and Validation of large scale SNP genotyping in pharmacogenetic analysis of anti-epileptic drugs.” Human Genetics Society of Australia, New Zealand (July 2007).
Kwan, P., Li, H. M., Gonzales, M., Kaye, A. H., Szoeke, C. E., Ng, H. K. and O'Brien, T. J. “Increased p-glycoprotein level in resected temporal neocortex correalates with ongoing pharmacoresistant seizures in patients with mesial temporal lobe epilepsy, Epilepsia 2004;49:467.
Szoeke, C., Bladin, C., Gordon, A., MacKay, M.Stroke presenting under 3 hours in patients younger than 18 years of age. J Clin Neurosci 2009;16(11):1481-2.
Szoeke, C. Sills, GJ., Kwan, P. Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: Data from international pharmacogenetic cohorts. Epilepsy 2009;50(7):1689-1696.
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